The human alpha-fetoprotein gene. Sequence organization and the 5' flanking region.
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چکیده
منابع مشابه
The rat alpha 1-fetoprotein gene: characterization of the 5'-flanking region and tandem organization with the albumin gene.
He have constructed a Sprague-Dawley rat qenoaic l ibrary in X EKBL4. The library (nonaraplified) was screened with rat AFP and albumin CDNAB. Thirty-three positive clones were characterized by restrict ion mapping and Southern analysis. The rat AFP gene spans «19 kb and i t ia located = 15 kb downstream from the albumin gene, with the same polarity of transcription. Transcription in i t ia t i...
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Previous studies have identified eight variant human GH receptor (hGHR) messenger RNA (mRNAs; V1-V8), that differ in their 5'-untranslated regions (5'UTRs) but splice into the same site just upstream of the translation start site in exon 2; thus, they encode the same protein. Here we report a novel variant, V9, and describe the mapping of all nine 5'UTR sequences within 40 kb upstream of exon 2...
متن کاملThe complete sequence of the chicken delta 1 crystallin gene and its 5' flanking region.
delta-Crystallin is the principal structural protein of the embryonic chicken lens. In the chicken, there are two linked delta-crystallin genes arranged in the same transcriptional polarity (5'-delta 1-delta 2-3'). Here we have sequenced the delta 1 crystallin gene and almost 4.3 kilobases of its 5' flanking region. The delta 1 gene is 7766 base pairs in length and has 17 exons. At least one la...
متن کاملMONOCLONAL ANTIBODIES TO HUMAN ALPHA-FETOPROTEIN
Alpha-fetoprotein (AFP), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. Monoclonal anti-AFP antibodies are essential reagents in developing appropriate techniques for measurement of this protein. In this study, in order to produce anti-AFP monoclonal a...
متن کاملNucleotide sequence of the 5'-flanking region of the murine ornithine decarboxylase gene.
We have sequenced a 1674basepair Pst I fragment ( 1 6 5 8 to +16, relative to the transcription start site) from the 5"-f1ank1ng region of the mouse ornithine decarboxylase (ODC) gene, Isolated from a genomtc library of BALB/c mice (generously provided by Dr. J. V. Ravetch). Previously, Brabant et al. ( 1 ) and Katz and Kahane ( 2 ) have reported sequences for the 5'-flank1ng region of this gen...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)89178-5